The Castel laboratory is interested in the molecular mechanisms underlying oncoprotein-mediated transformation.

Our laboratory uses biochemical, cell signaling, mouse models, and pharmacological approaches to elucidate the functions and regulation of different oncoproteins in cancer and congenital disorders.

We are particularly interested in the RAS family of GTPases, which are involved in mitogenic signaling and are notorious drivers of cancer and neurodevelopmental syndromes.